三甘-葡萄糖体重指数预测了ST升高心肌梗塞患者的预后
Ming Liu1,2, Jianyuan Pan1, Ke Meng1
1Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Scientific reports
|January 10, 2024
概括
三糖糖体质指数 (TyG-BMI) 可以预测经皮冠状动脉干预 (PCI) 的ST升高心肌梗塞 (STEMI) 患者的主要不良心血管事件 (MACE). 这个简单的指数提供了一种可靠的方法来评估MACE风险和预后.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 干预心脏病学 干预心脏病学
背景情况:
- 胰岛素抵抗 (IR) 是心血管疾病的一个关键因素.
- 三甘油糖体质量指数 (Triglyceride-glycemic-body mass index,TyG-BMI) 是一种被公认的替代标志物,用于检测IR.
- 在接受皮肤冠状动脉干预 (PCI) 的ST段升高心肌梗塞 (STEMI) 患者中,TyG-BMI的预后价值仍在研究中.
研究的目的:
- 评估Tyg-BMI指数在PCI后的STEMI患者的预后意义.
- 评估TyG-BMI在该患者队列中对主要心血管不良事件 (MACE) 的预测能力.
主要方法:
- 总共有2648名接受PCI的STEMI患者被纳入.
- TyG-BMI指数是使用禁食甘油三,禁食血葡萄糖和BMI计算的.
- 主要不良心血管事件 (MACE) 被定义为所有原因死亡,非致命的心肌梗塞,非致命中风和冠状动脉再血管化的复合.
主要成果:
- 193名患者在14.7个月的中位随访期间经历了MACE.
- 卡普兰-梅尔生存分析显示,在TyG-BMI三级动物中,MACE发生率存在显著差异 (p=0.019).
- 在中和最高TyG-BMI四分位数中,MACE的调整后危险比分分别为1.37和1.53,与最低四分位数相比. 在6个月,1年和3年预测MACE的曲线下的面积 (AUC) 分别为0.691,0.666和0.637. 添加TyG-BMI改善了风险预测模型.
结论:
- 在接受PCI的STEMI患者中,TyG-BMI指数与MACE独立相关.
- TyG-BMI 作为一种简单,可靠和有效的工具,用于评估这些患者的MACE风险和预后.
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