古代欧亚人的选择景观和遗传
Evan K Irving-Pease1, Alba Refoyo-Martínez2, William Barrie3
1Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. evan.irvingpease@gmail.com.
Nature
|January 10, 2024
概括
古人类在全新纪的进化过程中, 饮食和生活方式发生了重大变化. 遗传分析揭示了选择和迁移如何塑造欧洲人口,
科学领域:
- 人类的进化
- 人口遗传学
- 古代基因组学
背景情况:
- 全新纪 (始于约12,000年前) 见证了影响现代健康的显著人类进化变化.
- 了解从狩猎采集者到农业社会的转变过程中的遗传适应是至关重要的.
研究的目的:
- 模拟整个西欧亚的遗传选择景观.
- 研究当今欧洲人的表型多样性的遗传基础.
主要方法:
- 分析了1600多个被认为是古代的基因组.
- 与代谢 (FADS,LCT) 和免疫 (HLA) 相关的选择信号的建模.
- 在英国生物库样本中推断本地血统,并计算血统特定的多基因风险得分.
主要成果:
- 在FADS和LCT位点中确定了早期选择信号,先于乳糖持续性.
- 发现强烈的HLA区域选择可能与青铜时代病原体暴露有关.
- 证明了中石器,新石器和青铜器时代祖先在欧亚大陆的差异分布.
- 与草原祖先和新石器时代农民和西方狩猎采集者祖先的情绪/代谢疾病风险等位基因相关的身高变化.
结论:
- 古代的选择和迁移对现代欧洲人观察到的表型多样性做出了重大贡献.
- 对某些健康状况的遗传倾向可以追溯到特定的祖先群体.
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