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全免疫-炎症值在感染性休克患者的预后的重要性
1Department of Critical Care, Marmara University Faculty of Medicine, Pendik, Istanbul, 34899, Turkey. jasembozkurt@hotmail.com.
BMC infectious diseases
|January 10, 2024
概括
全免疫炎症值 (PIV) 可以预测败血症休克患者的生存时间更长. 然而,在多变量分析中,PIV与死亡率没有显著关联,尽管表明炎症.
科学领域:
- 关键护理医学 关键护理医学
- 生物标志物研究 生物标志物研究
- 炎症研究 炎症研究
背景情况:
- 系统性炎症是感染性休克的一个标志.
- 需要新的生物标志物来预测重症患者的结果.
- 全免疫炎症值 (PIV) 结合了常见的炎症指标.
研究的目的:
- 调查PIV对感染性休克ICU患者死亡率和预后的预测价值.
- 评估PIV与败血性休克生存时间的关联.
主要方法:
- 对82名被诊断患有败血性休克的成年ICU患者进行前性研究.
- 排除患有血性疾病和中性衰竭的患者.
- 使用中性细胞,血小板,单细胞和淋巴细胞计数计算PIV.
主要成果:
- 较低的PIV与更长的中位生存时间 (28天 vs. 16天) 有关.
- 在单变量分析中,高PIV,低格拉斯哥昏迷量表 (GCS),高顺序器官衰竭评估 (SOFA),高急性生理和慢性健康评估II (APACHE II),高乳酸和高公素 (PCT) 与生存率下降有关.
- 在多变量分析中,高乳酸盐和SOFA得分与较短的生存时间有显著的关联.
结论:
- PIV显示了作为在败血症休克中延长生存的预测因素的潜力.
- 虽然PIV反映了炎症,但在多变量分析中,它不是死亡率的重要独立预测因素.
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