在剖腹产过程中以斯凯特胺进行预治疗,可降低产后抑郁症的发生率:随机对照的临床试验
Shixia Xu1,2, Jiaojiao Yang2, Jing Li2
1Department of Anesthesiology, Nanjing Medical University, Nanjing, 210000, Jiangsu, China.
BMC anesthesiology
|January 10, 2024
概括
术中使用的石胺在4天后降低了产后抑郁症的发生率,并在剖腹产后降低了疼痛评分. 然而,头和视力模糊等副作用增加,42天后没有持续的抑郁症预防.
科学领域:
- 麻醉学 麻醉学
- 产科 产科 产科 产科 产科
- 精神病学是一个精神病学.
背景情况:
- 产后抑郁症 (PPD) 是女性心理健康的一个重大问题.
- 氨酸在PPD中表现出快速抗抑郁作用.
- 乙胺,一种胺反体,正在研究在剖腹产期间预防PPD.
研究的目的:
- 评估手术期间使用的石胺在减少PPD发病率方面的疗效.
- 评估胺对术后疼痛管理的影响.
- 为了记录和比较与埃斯基坦胺管理相关的不良事件.
主要方法:
- 一项随机对照试验,涉及319名接受剖腹产分娩的产妇.
- 参与者被分配给接受胺 (0.2毫克/公斤) 或液安慰剂.
- 使用爱丁堡产后抑郁症量表 (EPDS) 评估PPD,使用数值评分量表 (NRS) 评估疼痛.
主要成果:
- 在产后4天后,PPD的发病率在乙胺组显著降低 (13.8%与23.1%,P=0.0430).
- 埃斯凯特胺可在6小时,12小时和24小时后降低术后疼痛评分,并降低了对血管活性药物的需求.
- 增加的孕产妇副作用包括头,视力模糊和昏昏欲睡在埃斯基坦胺组观察到.
结论:
- 术中使用的乙胺 (0.2 mg/kg) 有效地减少了产后4天的PPD发病率,并缓解了手术后的疼痛.
- 产后42天后,艾斯基坦胺的抗抑郁作用没有持续.
- 乙胺的使用与母亲的副作用的发病率更高有关.
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