解开药物贡献:与个人药物相关的老年人抗胆固醇负担:一个基于人口的横截面研究
Gauri Bhatkhande1,2, Niteesh K Choudhry1,2, Mufaddal Mahesri1
1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA.
大多数老年人从混合药物中积累了高的抗胆固醇负担,而不仅仅是强药. 较轻的抗胆固醇药物显著增加了这种负担,突出了对老年人更好的处方做法的需要.
科学领域:
- 老年学是指老年学的学科.
- 临床药房 临床药房
- 公共卫生 公共卫生
背景情况:
- 有效的抗胆固醇药物与不良反应有关.
- 同时使用多种较弱的抗胆固醇药物可能导致高累积负担.
- 识别高抗胆固醇负担的模式和相关的患者特征至关重要.
研究的目的:
- 在老年人中识别高抗胆固醇负担的模式.
- 为了确定与不同抗胆固醇负担模式相关的患者特征.
- 为改善老年人抗胆固醇药物处方的干预措施提供信息.
主要方法:
- 在2019年确定了65岁以上的患者,累计抗胆固醇负担 (ACB) 评分≥4在2019年.
- 将患者分为三组:只有中度/强度的ACB,只有轻度/可能的ACB,或混合.
- 使用多项逻辑回归来评估与每个组相关的患者特征,以中度/强度组作为参考.
主要成果:
- 91.2%的高抗胆固醇负担患者使用了混合药物类型.
- 在混合组中,轻度/可能抗胆固醇剂占填充剂的64.3%.
- 与中度/强度组相比,仅使用轻度/可能抗胆固醇药物的患者年龄较大,女性的可能性较小,患病并发症较多,并访问医生的次数较少.
结论:
- 高抗胆固醇负担在老年人中主要是由轻/可能和中度/强抗胆固醇药物的组合驱动的.
- 轻度/可能的抗胆固醇药物是整体抗胆固醇负担的主要贡献者.
- 这些发现可以指导干预措施,以优化对老年人群的抗胆固醇药物处方.
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