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核桃消费对成年人内皮功能标志物的影响:随机对照试验的系统审查和元分析
Chou-Yi Hsu1, Abdullah Ali Alzahrani2, Hatem Ghaleb Maabreh3
1Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
Phytotherapy research : PTR
|January 10, 2024
概括
核桃消费显著改善内皮功能,通过增加流介导扩张 (FMD),这是心血管健康的关键指标. 然而,核桃对其他标志物,如ICAM-1和VCAM-1没有显示好处.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 内皮功能研究研究 内皮功能研究
背景情况:
- 关于核桃消费对内皮功能的影响存在相互矛盾的发现.
- 内皮功能障碍是心血管疾病发展的关键因素.
研究的目的:
- 系统地审查和元分析关于核桃摄入量和内皮功能现有的试验.
- 评估核桃对流媒扩张 (FMD) 和特定炎症标志物的影响.
主要方法:
- 在主要数据库 (PubMed-Medline,Scopus,Web of Science) 进行了系统的文献搜索,直到2023年10月.
- 包括报道了关于核桃摄入量及其对口,ICAM-1,VCAM-1和SARM的影响的研究.
- 随机效应模型被用于对加权平均差异 (WMD) 和标准化平均差异 (SMD) 的元分析.
主要成果:
- 分析了6项涉及250名参与者的试验.
- 核桃摄入量对口病有显著的积极影响 (WMD:0.94%,p=0.02).
- 对于ICAM-1,VCAM-1或SARM,没有发现显著的益处.
结论:
- 核桃的消费可能有助于通过改善口炎,降低心血管疾病的风险.
- 需要进一步的研究才能充分阐明核桃对成人内皮功能的影响.
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