补充疗法及其与常规合成DMARDs在类风湿性关节炎中的治疗坚持问题的关联:一个横截面研究
Aline Priscilla Santiago-Garcia1,2, Jorge Ivan Gamez-Nava1,2,3,4, Felipe Alexis Avalos-Salgado1,2
1Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Healthcare (Basel, Switzerland)
|January 11, 2024
概括
使用补充疗法的类风湿性关节炎 (RA) 患者面临不遵守传统治疗的更高风险. 早期识别和讨论风险对医疗保健提供者至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 综合医学是一个整体的医学.
- 患者的坚持 患者的坚持
背景情况:
- 在类风湿性关节炎 (RA) 患者中,使用补充疗法是常见的.
- 补充医学和科学公认的治疗方法之间存在潜在的冲突.
- 有限的数据解决了非传统疗法和治疗合规性之间的联系.
研究的目的:
- 确定辅助疗法的使用是否会增加RA患者传统合成疾病修饰性抗风湿药物 (cs-DMARDs) 治疗不良坚持的风险.
- 调查非传统疗法利用与坚持挑战之间的关联.
主要方法:
- 在一所大学医院的风湿病诊所对250名RA患者进行了调查.
- 收集的数据包括补充疗法使用 (类型,患病率),坚持 (莫里斯基-格林尺度) 和临床特征.
- 单变量和多变量逻辑回归模型分析了补充疗法使用者的坚持风险.
主要成果:
- 92%的RA患者使用补充疗法,最常见的是草药 (65%),顺势疗法 (64%) 和大麻衍生品 (51%).
- 无变量分析将年龄,并发症和补充疗法使用与坚持问题联系起来.
- 多变量分析证实,补充疗法使用显著增加了对cs-DMARDs缺乏坚持的风险 (调整后OR = 2.84,p = 0.037).
结论:
- 补充疗法的使用与RA患者治疗粘附问题的显著更高风险有关.
- 医生应主动确定RA患者的补充疗法使用情况.
- 关于补充疗法的风险和益处的公开讨论对于知情的患者护理至关重要.
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