在临床实践指南 (CPG) 中的生物医学方法中,性别是否重要? :西班牙国家卫生系统中使用的方法论文件的系统审查
Ana M González Ramos1, Gema Serrano-Gemes2
1Institute for Advanced Social Studies (IESA), The Spanish National Research Council (CSIC), 14004 Córdoba, Spain.
Healthcare (Basel, Switzerland)
|January 11, 2024
概括
临床实践指南往往忽视了关键的性别和性别健康差异. 本次审查强调需要将这些证据整合到全面的患者护理和疾病管理中.
科学领域:
- 健康研究方法的方法论.
- 临床实践指导方针的制定.
- 卫生公平性健康公平性
背景情况:
- 性别和性别是关键的健康决定因素,但它们在医疗实践和指导方针中的整合仍然缓慢.
- 现有的文献表明,临床实践指南不充分地解决了性别和性别方面的考虑.
- 这种差距可能导致忽视影响健康和疾病结果的重要证据.
研究的目的:
- 在制定临床实践指南时,系统地审查性别和性别维度的相关性.
- 评估方法论文件如何解决性别和性别证据的纳入问题.
- 确定在准则制定中需要改进的领域,以确保全面考虑健康问题.
主要方法:
- 对临床实践准则制定方法论文件的系统审查.
- 基于三个主要来源的分析:AGREE报告清单,GRADE手册和西班牙语的GuíaSaludNHS临床指南计划.
- 评估这些文件如何纳入性别和性别方面的考虑.
主要成果:
- 临床实践指南的方法论文件提供了关于纳入性别和性别问题的有限指导.
- 根据AGREE报告清单,GRADE手册和GuíaSalud计划,没有明确强调这些方面.
- 这种监督导致可能排除了重要的性别和性别特异性健康证据.
结论:
- 在生物医学方法中忽视性别和性别延续了对关键证据的监督.
- 必须加强临床实践指导方针,以系统地包括性别和性别维度.
- 整合这些因素对于提高医疗保健和疾病管理的准确性和公平性至关重要.
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
129
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
129
Disorders of the Male Reproductive System
419
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
419
Factors Affecting Drug Biotransformation: Biological
153
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
153
Spermatogenesis
102.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.5K
Psychosurgery
56
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
56
Standard Precaution
1.9K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
1.9K


