对药物诱导性病的真实数据衍生药监测评估:对患者护理差距的影响
Yujin Kim1, Chang-Young Choi2, Yongjun Sunwoo3
1Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Healthcare (Basel, Switzerland)
|January 11, 2024
概括
药物诱导的毒性是一个严重的问题,像环素这样的免疫抑制剂比抗生素带来更高的风险. 老年妇女和服用多种药物的妇女面临更高的风险.
科学领域:
- 药物监督 药物监督 药物监督
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床药理学 临床药理学
背景情况:
- 药物不良事件 (ADEs) 对健康构成重大风险,特别是药物诱导的毒性.
- 了解毒性患病率,严重程度和预测因素对于患者安全至关重要.
研究的目的:
- 调查药物诱导毒性的流行和严重性.
- 确定与严重毒性相关的临床预测因素.
主要方法:
- 从2012年至2021年使用韩国不良事件报告系统数据库 (KAERS DB) 进行了回顾性横截面研究.
- 不成比例性分析 (报告几率比率) 来评估可归因于药物的严重性.
- 后勤回归用于识别严重毒性的预测因素.
主要成果:
- 免疫抑制剂是毒性最常见的原因.
- 抗生素,包括菌素,不太可能引起严重的毒性 (ROR 0.268).
- 与环素相关的副作用主要是严重的 (93%),而塔克罗利斯的严重性较低 (ROR 0.356).
- 年龄较大降低了风险 (ROR 0.955),而女性性别增加了风险 (OR 2.700).
- 多药与间歇性炎风险增加有关 (OR 1.019).
结论:
- 与塔克罗利和抗生素相比,环素具有严重药物诱导毒性高风险.
- 女性性别,年轻年龄和多药性是严重毒性的重要预测因素.
- 需要进一步研究临床实践影响和毒性预后.
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