对肠道微生物组和短链脂肪酸进行标准化口服石榴提取物的前性随机,双盲,安慰剂控制研究
Raja K Sivamani1,2,3,4, Mincy Chakkalakal1, Adrianne Pan1,3
1Integrative Skin Science and Research, Sacramento, CA 95815, USA.
Foods (Basel, Switzerland)
|January 11, 2024
概括
在健康的成年人中补充石榴提取物增加了有益的肠道细菌和循环中的短链脂肪酸水平,如 propionate. 这表明石榴.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
背景情况:
- 石榴 (Punica granatum L.) 富含多,包括基和酸,以抗氧化和免疫调节作用而闻名.
- 肠道微生物群将埃拉基坦宁代谢成乌罗,这可能对健康有好处.
- 石榴提取物对肠道微生物群,短链脂肪酸 (SCFA) 和urolithin生产的影响需要进一步调查.
研究的目的:
- 为了评估标准化尼卡拉丰富石榴提取物 (Pomella®) 对肠道微生物群,循环中的SCFA和健康成年人的urolithins的影响.
主要方法:
- 这是一项为期4周的随机,双盲,安慰剂控制的研究,每天补充75毫克的普尼卡拉.
- 通过便和血液样本分析肠道微生物组合,循环中的SCFA (propionate, acetate) 和urolithins.
- 这项研究招募了25-55岁的健康志愿者.
主要成果:
- 没有观察到整体肠道微生物多样性的显著变化.
- 发现了有益细菌的相对丰度的显著增加,包括Faecalibacterium prausnitzii.
- 石榴提取物补充剂增加了循环中的酸盐水平,并显示了增加酸盐的趋势,以及更高的循环urolithins.
结论:
- 补充富含普尼卡拉的石榴提取物可以调节肠道微生物组合,并提高SCFA和urolithins的循环水平.
- 这些发现表明,通过肠道微生物相互作用和代谢产生的潜在健康益处.
- 需要在更大的队列和较长时间内进行进一步的研究来证实这些效应.
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