淋巴内皮细胞VEGFR3信号在疾病中的失调
Kevin Kuonqui1, Adana-Christine Campbell1, Ananta Sarker1
1Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cells
|January 11, 2024
概括
血管内皮生长因子受体3 (VEGFR3) 信号传递对淋巴血管健康至关重要. VEGFR3的失调与淋巴和癌症等疾病有关,提供治疗点.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 血管生物学 血管生物学
背景情况:
- 血管内皮生长因子受体3 (VEGFR3),由FLT4基因编码的受体氨酸激酶,对于淋巴血管的发育和维护至关重要.
- 在淋巴内皮细胞 (LEC) 上与VEGFR3结合的VEGF-C和VEGF-D激活PI3K-Akt和MAPK-ERK通路,促进淋巴细胞的增殖,迁移和生存.
- 损害VEGFR3信号与许多临床条件有关.
研究的目的:
- 提供LEC中细胞内VEGFR3信号的概述.
- 探索VEGFR3信号失调在各种疾病状态中的作用.
- 突出开发针对VEGFR3.3的新型治疗策略的潜力.
主要方法:
- 对VEGFR3信号通路的现有文献的审查.
- 在正常和病理条件下分析VEGFR3的作用.
- 鉴定与VEGFR3功能受损相关的疾病.
主要成果:
- VEGFR3信号传递对于淋巴内皮细胞功能至关重要.
- 失调的VEGFR3信号与淋巴,瘤生长和转移,肥胖和代谢综合征,器官移植排斥和自身免疫性疾病有关.
- 了解这些分子机制是开发新治疗方法的关键.
结论:
- 在淋巴系统的恒温和疾病中,VEGFR3起着至关重要的作用.
- 准VEGFR3信号通路为治疗一系列慢性和衰弱性疾病提供了一个有希望的途径.
- 进一步研究由VEGFR3功能障碍驱动的淋巴病理的分子基础是有必要的.
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
03:14Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K