通过B细胞调节对亚托皮性皮肤炎的桃体衍生性介质干细胞的免疫调节作用
Dong-Kyu Kim1,2, Hyun-Joo Lee2, Il Hwan Lee1
1Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Cells
|January 11, 2024
概括
桃体衍生的中干细胞 (T-MSCs) 有效地抑制了在亚托皮炎模型中的免疫反应. 这些细胞调节B细胞激活和IgE产生,为AD提供了潜在的新疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
- 皮肤病学 皮肤病学
背景情况:
- 介酶干细胞 (MSCs) 调节免疫反应.
- 桃体衍生MSCs (T-MSCs) 由于可访问性和低免疫性而具有前景.
- 皮炎 (AD) 中T-MSCs的治疗潜力需要进一步研究.
研究的目的:
- 为了研究原始化T-MSCs在亚托皮性皮炎 (AD) 病变发生中的免疫调节作用.
- 在AD模型中,比较了原始化T-MSC与原始化T-MSC的疗效.
- 阐明在AD中B细胞反应的T-MSC介导调节背后的机制.
主要方法:
- 动物研究评估了原始化的T-MSCs的免疫抑制作用.
- 在体外实验评估B细胞增殖和抗体产生.
- 使用CD40敲击模型,研究CD40在T-MSC介导的B细胞调节中的作用.
- 对非正规NF-κB通路参与的分析.
主要成果:
- 在动物模型中,与原始的T-MSC相比,原始的T-MSC显示出更强的免疫抑制作用.
- 化T-MSCs在体外显著降低了B细胞的增殖和IgE的产生.
- 在原始化的T-MSCs上的CD40被确定为通过非正规NF-κB通路调节B细胞激活的关键.
结论:
- 开的T-MSC显示出治疗亚托皮性皮肤炎的显著治疗潜力.
- 该机制涉及B细胞介导的炎症反应的调节.
- 通过非正规NF-κB途径调解的CD40表达在原始化的T-MSC上,是它们有效性的关键.
相关概念视频
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Cells of the Adaptive Immune Response
989
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
989
T Cell Activation and Clonal Selection
739
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
739
Cell-mediated Immune Responses
68.3K
Overview
68.3K


