相关实验视频
Updated: Jul 6, 2025

05:21
Establishment of A Mouse Model of Aqueous Deficiency Dry Eye
Published on: November 1, 2024
592
在水性缺陷干眼中,中枢角膜上皮损伤引起的眼睛疼痛
Yamato Yoshikawa1,2, Norihiko Yokoi2, Natsuki Kusada2
1Department of Ophthalmology, Osaka Medical and Pharmaceutical University, Takatsuki-City 569-8686, Japan.
Diagnostics (Basel, Switzerland)
|January 11, 2024
概括
在干眼疾病中的量化疼痛测量显示,眼睛疼痛和角膜染色之间存在显著的相关性. 点性闭塞有效地减少了疼痛,突出了中枢角膜上皮损伤作为缺水干眼的关键因素.
科学领域:
- 眼科医生 眼科 眼科
- 疼痛医学 医学 疼痛医学
- 医疗器械 医疗器械
背景情况:
- 缺水干眼 (ADDE) 是一种常见的情况,其特点是眼部不适.
- 对眼痛 (EP) 的客观测量及其与ADDE患者临床症状的相关性需要进一步研究.
- 定量疼痛测量装置PainVision®提供了一种评估EP严重程度的新方法.
研究的目的:
- 使用定量PainVision®设备评估ADDE患者眼痛 (EP) 的严重程度.
- 评估EP与ADDE中的客观临床发现之间的相关性.
- 为了确定点性阻塞对EP的影响以及相关的客观发现.
主要方法:
- 招募了53名ADDE患者 (53只眼睛).
- 用PainVision® (疼痛程度 (PD)) 测量了眼痛 (EP) 的严重程度.
- 评价了角膜染色,眼擦拭器上皮病和撕裂半月膜半径,18名患者经历了点性闭塞.
主要成果:
- 在ADDE患者中,PD的中位数为30.6μA/μA.
- 显著相关的PD与鼻腔和中部角膜染色和上眼皮擦拭器上皮质病 (p < 0.05).
- 中央角膜染色得分是影响PD的最重要因素. 点性闭塞显著降低了PD (中位数为24.8至7.1μA/μA;p < 0.0001).
结论:
- 使用PainVision®对ADDE患者进行定量疼痛测量是可行的.
- 中央角膜上皮损伤与ADDE相关的眼睛疼痛密切相关.
- 点性闭塞有效地缓解ADDE患者的眼痛.
相关概念视频
Glaucoma: Overview
574
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
574
Angle Closure Glaucoma: Treatment
500
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
500
Open Angle Glaucoma: Treatment
453
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
453
Accessory Structures of the Eye
1.6K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.6K

