预后营养指数与慢性肝病患者的肝功能和预后相关
Masahiro Matsui1, Akira Asai1,2, Kosuke Ushiro1
1The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Osaka, Japan.
Diagnostics (Basel, Switzerland)
|January 11, 2024
概括
预后营养指数 (PNI) 有效预测慢性肝病 (CLD) 患者的生存率. 低于40的PNI表明预后较差,强调了其在评估营养状况和患者结果方面的价值.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床营养学 临床营养学
- 在瘤学瘤学.
背景情况:
- 预后营养指数 (PNI) 是一个公认的营养查工具.
- 它在慢性肝病 (CLD) 患者,包括肝细胞癌 (HCC) 患者中的实用性需要进一步研究.
研究的目的:
- 评估PNI在患有CLD的患者的预后价值.
- 在这个队列中确定与低PNI (<40) 相关的因素.
主要方法:
- 对319名CLD患者进行了回顾性观察研究 (平均年龄为71岁,153人患有HCC).
- 分析PNI与白蛋白-白素 (ALBI) 评分和等级的相关性.
- 多变量分析以确定与PNI<40相关的因素.
- 接收器操作特征 (ROC) 曲线分析用于生存预测.
主要成果:
- 普尼显示与ALBI分数和成绩有很强的相关性.
- 对于PNI ≥40 (93.2%) 的1年生存率明显高于PNI<40 (65.5%) (p <0.0001).
- 血红蛋白,HCC的存在和ALBI得分是PNI<40的独立预测因素.
- 在ROC分析中,生存预测的最佳PNI截止值为42.35 (AUC=0.79).
结论:
- 在CLD患者中,PNI是营养状况的有价值指标.
- PNI < 40 是CLD预后不佳的重要预测因素,包括HCC患者.
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