环境温度与胃食道癌的存活率之间的关联:一个基于人口的研究
Kush Gupta1, Anthony George2, Kristopher Attwood2
1Department of Internal Medicine, Umass Chan Medical School-Baystate, Springfield, MA 01199, USA.
Cancers
|January 11, 2024
概括
温暖的气候与食道癌 (EC) 和胃癌 (GC) 患者的更好的生存率有关. 较高的年平均温度 (AAT) 显著提高了整体生存率 (OS) 和疾病特异性生存率 (DSS).
科学领域:
- 在瘤学瘤学.
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 寒冷压力会损害抗瘤反应,促进瘤生长.
- 现有研究表明,年平均温度 (AAT) 与癌症发病率之间存在负相关性.
- 这项研究调查了气候对食道癌 (EC) 和胃癌 (GC) 患者的生存结果的影响.
研究的目的:
- 为了确定生活在温暖气候中的EC和GC患者与生活在寒冷气候中的患者相比,是否表现出更好的生存率.
- 在胃食道癌患者中分析AAT与整体生存率 (OS) 和疾病特异性生存率 (DSS) 之间的关联.
主要方法:
- 从SEER数据库 (1996-2015) 中对17408名EC和20553名GC患者进行了回顾性分析.
- 县级AAT数据来自国家环境信息中心.
- 考克斯多变量回归模型被用来评估AAT与存活率之间的关系,并对共变量进行调整.
主要成果:
- 在AAT>53.5°F地区的患者显示,OS有11%的改善,EC的DSS有13%.
- 对于GC患者来说,AAT>53.5°F与13%的生存状况改善和14%的DSS相关.
- 每增加5°F的AAT都与两种癌症类型的OS和DSS均有3-4%的改善有关.
结论:
- 更高的环境温度与胃食道癌症患者的改善OS和DSS显著相关.
- 这些发现突出了一个潜在的环境因素影响癌症患者的结果.
- 需要进一步的研究来证实这些结果并探索潜在的治疗策略.
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