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Updated: Jul 6, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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表观遗传变化是博特佐米布分子作用的重要方面

Piotr Kulig1, Karolina Łuczkowska1, Estera Bakinowska1

  • 1Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.

Cancers
|January 11, 2024
PubMed
概括

博尔特佐米布 (BTZ) 通过抑制蛋白质降解来治疗多发性髓瘤. 本综述探讨了BTZ诱导的表观遗传变化,影响其疗效,耐药性和副作用,并建议新的治疗点.

关键词:
博尔特佐米布 (Bortezomib) 是一种药物.药物耐药性 耐药性 药物耐药性这是表观遗传学.甲基化处理的方法没有编码的RNA.蛋白酶体抑制剂是一种蛋白酶体抑制剂.

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