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与肠道粘膜损伤的初始阶段相关的综合便微生物群概况:试点研究

Sergio Ruiz-Saavedra^1,2, Silvia Arboleya^1,2, Alicja M Nogacka^1,2

¹Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300 Villaviciosa, Spain.

|January 11, 2024

概括

早期的肠粘膜损伤先于结直肠癌 (CRC). 便微生物群分析显示肠道细菌,特别是常规腺瘤的显著变化,表明早期肠道健康变化.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
在瘤学瘤学.

背景情况:

结肠直肠癌 (CRC) 的发展是一个漫长的过程,涉及渐进的肠粘膜损伤.
目前的临床实践依赖于内镜查和组织病理学来评估粘膜病变和CRC风险.
了解早期的微生物变化对于及时干预和预防策略至关重要.

研究的目的:

调查便微生物群组成和短链脂肪酸 (SCFA) 水平在肠粘膜变化的早期阶段的变化.
为了比较非病理性对照,超塑性息肉和常规腺瘤之间的微生物概况.
为了将微生物变化与常规腺瘤中形的组织病理学等级相关联.

主要方法:

便微生物群的基于16S rRNA基因的元分类学分析.
气相色谱用于便样本中SCFA的量化.
结肠镜检查和肠道组织的组织病理学检查.

主要成果:

观察到来自Bacillota和Euryarchaeota类的微生物种群的显著变化.
传统的腺瘤表现出更深刻的微生物群变化,而不是超塑性息肉.
鲁米诺球菌扭矩在两种多类型中都得到了丰富,而Eggerthellaceae则是特异性的超塑性多.
特定的细菌家族 (例如,Prevotellaceae,Oscillospiraceae) 在常规腺瘤中转移与失质等级,独立于SCFA水平.

结论:

早期的肠粘膜变化与明显的便微生物群重组有关.
特定的微生物种群变化可能作为癌前病变的早期指标.
肠道微生物组在结直肠癌的早期发病过程中发挥着作用,在显著的SCFA水平变化之前.

关键词:

传统的腺瘤.便中的微生物群过度塑性多样体的多样体.肠道粘膜中的肠道粘膜.肠道多重体是一种肠道多重体.

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