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用免疫检查点抑制剂治疗转移性黑色素瘤的预测因素:从临床实践到未来的视角

Stefano Poletto¹, Luca Paruzzo^2,3, Alessandro Nepote¹

¹Department of Oncology, University of Turin, AOU S. Luigi Gonzaga, 10043 Orbassano, Italy.

|January 11, 2024

概括

预测因素对于识别可能对转移性黑色素瘤中免疫检查点抑制剂 (ICI) 产生反应的患者至关重要. 研究探索宿主,免疫和瘤因素,以个性化ICI治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

免疫疗法,特别是免疫检查点抑制剂 (ICI),已经改变了转移性黑色素瘤的治疗方法.
然而,对ICI的反应率各不相同,因此需要确定预测性生物标志物.

研究的目的:

批判性地审查当前关于ICI响应转移性黑色素瘤预测因素的文献.
评估各种预测生物标志物的潜力和局限性.

主要方法:

综合文献综述研究的研究调查的预测因素在转移性黑色素瘤治疗ICIs.
分析与宿主相关的,与免疫系统激活相关的和与瘤相关的因素.
评估生物标志物,包括病史,肠道微生物组,瘤负担标志物和免疫细胞概况.

主要成果:

预测因素包括患者的人口统计学,并发症,肠道微生物组合,瘤负担 (例如LDH,CRP,ctDNA) 和瘤特征 (例如TIL,突变).
免疫系统激活标记物,如IFN-马基因表达和循环免疫细胞子集,与ICI反应有显著的相关性.
各种方法都有局限性和潜力,需要仔细考虑.

结论:

确定预测因素对于优化转移性黑色素瘤ICI治疗至关重要.
有前途的生物标志物正在出现,为改善患者选择和治疗分层提供了潜力.
需要进一步的研究来验证并将这些生物标志物纳入临床实践.

关键词:

生物标志物生物标志物免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法黑色素瘤是一种黑色素瘤.预测因素是一个预测因素.

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