科布雷斯特测试是一种快速诊断,预后和预测方法,用于对全身治疗的反应
Anna Tankiewicz-Kwedlo1, Tomasz Lobacz2, Leszek Kozlowski2
1Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222 Bialystok, Poland.
在治疗前使用简单的测试,ONCOBREAST-TEST可以准确预测乳腺癌的化学敏感性. 这种个性化的方法可以优化化疗,减少副作用并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
- 个性化医疗是个性化的医疗.
背景情况:
- 乳腺癌治疗依赖于化疗,但预测药物反应具有挑战性.
- 目前的方法在确定个体瘤化学敏感性方面缺乏准确性.
- 个性化治疗旨在为更好的疗效和减少毒性量身定制治疗.
研究的目的:
- 推出ONCOBREAST-TEST,这是乳腺癌的新型诊断和治疗程序.
- 在化疗前评估分离的乳腺癌细胞的化学敏感性.
- 为了实现个性化的治疗选择,以改善患者的治疗结果.
主要方法:
- 使用了MTT测定,形态评估,LDH活性和流细胞计 (细胞亡,增殖,细胞标记物,Ki-67).
- 开发了用于预测瘤细胞化学敏感性的诊断面板.
- 综合结果为简单,最少侵入性和快速评估.
主要成果:
- 乳腺癌试验准确地预测了乳腺癌细胞的化学敏感性.
- 确定了最佳疗法:用于G3 NOS的多塞塔克塞尔/cyclophosphamide,用于G1 NOS的帕克利塔克塞尔+/-特拉斯图祖马布.
- 证明了个性化化疗选择的潜力.
结论:
- 乳腺瘤测试提供了一种简单,快速和准确的方法来评估乳腺癌的化学敏感性.
- 允许个性化治疗选择,增加化疗的有效性.
- 减少副作用,保护患者健康,缩短治疗时间,产生经济和社会效益.
更多相关视频
10:35A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
Published on: April 5, 2018
07:44Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
Published on: March 12, 2018
相关概念视频
Treatment Resistant Cancers
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
