在Oligometastatic非小细胞肺癌中,白内障和肉症:使潜在的可治愈疾病变得无法治愈?
Valentina Bartolomeo1,2,3, Mandy Jongbloed4, Wouter R P H van de Worp5
1Radiation Oncology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Cancers
|January 11, 2024
概括
晚期非小细胞肺癌 (NSCLC) 患有同期寡细胞扩散性疾病 (sOMD) 的甲状腺和肉类没有显著影响存活率. 高C反应蛋白 (CRP) 可能是这些患者生存的预后因素.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 老年病的医生 老年病的医生
背景情况:
- 同步寡细胞扩散性疾病 (sOMD) 是一种高级非小细胞肺癌 (NSCLC) 的子集,在诊断时具有有限数量的转移.
- 卡切西亚和沙科佩尼亚与癌症患者的生存结果不佳有关.
- 整合卡赫西亚和萨科佩尼亚状态可能有助于在sOMD中进行激进治疗的治疗决策.
研究的目的:
- 追溯评估卡赫西亚和/或肉症与足够阶段的sOMD患者的存活率之间的关系.
- 为了确定潜在的预后因素,如C-反应蛋白 (CRP),对于这个患者群体的生存.
主要方法:
- 对234名在2015-2021年期间被诊断患有sOMD的患者进行了回顾性多中心研究,符合EORTC标准,并进行了适当的分期 (FDG-PET,脑成像).
- 估计卡赫西亚和萨科佩尼亚的患病率.
- 多变量分析,以评估白血病,肉症和高CRP与无进展生存率 (PFS) 和整体生存率 (OS) 的关联.
主要成果:
- 在19.7%的患者中,卡切西亚存在,在14.5%的患者中,萨科佩尼亚存在,在9.0%的患者中,两者都存在.
- 中位数PFS为8.6个月,中位数OS为17.3个月.
- 卡切西亚和萨科佩尼亚与较低的生存率没有显著关联. 高CRP显示与低生存率有关.
结论:
- 不管进行了激进治疗,卡切西亚和肉症对sOMD患者的存活率没有显著影响.
- 高CRP水平可以作为预后因素,可能有助于临床医生选择患者进行进一步治疗.
- 由于本研究的样本规模较小,需要对更大的子组进行进一步的研究.
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