叶酸摄入量对炎症性肠病患者骨矿物质密度的影响
Alicja Ewa Ratajczak-Pawłowska1,2,3, Aleksandra Szymczak-Tomczak1, Michał Michalak4
1Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Nutrients
|January 11, 2024
概括
在炎症性肠病 (IBD) 患者和对照组中,缺乏叶酸摄入是常见的. 叶酸摄入量与克罗恩病患者的骨矿物密度有积极的相关性,但其对IBD BMD的整体影响尚不清楚.
科学领域:
- 营养科学 营养科学
- 骨的新陈代谢 骨的新陈代谢
- 胃肠病学 胃肠病学
背景情况:
- 骨矿物质密度 (BMD) 的降低在炎症性肠病 (IBD) 中很普遍.
- 研究了IBD患者缺乏叶酸摄入量和BMD之间的潜在联系.
研究的目的:
- 与健康对照组相比,评估克罗恩病 (CD) 和性结肠炎 (UC) 患者的叶酸摄入量.
- 在这些群体中调查叶酸摄入量与骨矿物质密度 (BMD) 之间的关联.
主要方法:
- 在26名CD,30名UC和31名对照参与者中,使用4天24小时的饮食回忆评估了饮食摄入量,包括叶酸.
- 测量骨矿物质密度 (BMD),T评分和腰椎和大腿的Z评分.
- 叶酸补充剂的使用是通过问卷记录的.
主要成果:
- 在两组之间观察到体重,BMI,CRP,BMD,Z-score和T-score的显著差异.
- 两组之间没有发现总体能量或叶酸摄入量的差异.
- 叶酸摄入量不足很普遍,影响了70%的UC,92%的CD和77%的对照参与者.
- 每1000千卡的叶酸摄入量与CD组的腰椎BMD和T-score正相关.
结论:
- 缺乏叶酸摄入量是IBD患者和健康人群中普遍存在的问题.
- 叶酸对IBD患者的骨硬化特异性影响需要进一步研究.
- 需要进一步的研究来澄清叶酸摄入量,叶酸水平和IBD中的BMD之间的关系.
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