鱼油对肠道乳液补充剂对食道切除术后炎症参数的影响
Ana Suárez-Lledó Grande1, Josep M Llop Talaveron1, Elisabet Leiva Badosa1
1Pharmacy Department, Bellvitge University Hospital, University of Barcelona-IDIBELL, 08907 L'Hospitalet de Llobregat, Spain.
Nutrients
|January 11, 2024
概括
欧米茄-3脂肪酸 (ω-3FA) 没有影响食道切除术后的早期术后炎症,但是安全的. 需要进一步的研究来探索 ω-3FA 在手术恢复中的长期影响.
科学领域:
- 手术营养是指手术营养.
- 免疫营养 免疫营养 免疫营养
- 胃肠道手术 胃肠道手术
背景情况:
- 消化管切除术 (EPG) 与显著的术后发病率和死亡率有关.
- 欧米茄-3脂肪酸 (ω-3FA) 被认为具有减轻术后并发症的潜力.
- 在食道切除术后对-3FA进行管内注射是未研究的.
研究的目的:
- 为了评估亲肠道鱼油脂乳液 (LE) 与肠道营养相结合对食道切除术后术后结果的影响.
- 评估不同剂量和组成的 ω-3FA LE 对炎症标志物和安全性的影响.
主要方法:
- 一项随机对照试验,涉及三组接受不同的脂质乳液 (鱼油和LCT/MCT混合物) 或对照组.
- 在多个术后时间点测量炎症标志物 (IL-6,CRP,TNF-α,IL-10,IL-8,CD25s).
- 分析安全性,营养参数和并发症.
主要成果:
- 腹腔 ω-3FA 在短期内没有显著改变早期的术后炎症反应.
- 虽然观察到IL-6和CRP的整体时间变化,但这些变化并没有被LE类型或重症监护患者一致调节.
- ω-3FA的使用是安全的,并显示出改善高甘油三血的潜力,剂量取决于剂量.
结论:
- 在研究的时间范围内,通过肠道给药的 ω-3 脂肪酸 (ω-3FA) 似乎不会影响食道切除术后的早期炎症反应.
- 这种干预被认为是安全的,对过高甘油三血症有有益影响.
- 长期研究是有必要的,以充分阐明 ω-3FA 在手术恢复和炎症调节中的作用.
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