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晨钟型和肠道微生物群之间的因果关系:双向的双样本孟德尔随机化研究

Manman Chen¹, Zhenghe Wang², Din Son Tan³

¹School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

|January 11, 2024

概括

早晨的时刻型似乎可以防止某些肠道细菌,包括Bacteroidaceae家族和Bacteroides属. 这项研究表明,时间型和肠道微生物群组成之间存在因果关系,需要进一步调查.

科学领域:

人类微生物组研究研究
时间生物学时间生物学
遗传流行病学遗传流行病学

背景情况:

观察性研究将昼夜节律与肠道微生物群组成联系起来.
清晨时代型和肠道微生物群之间的因果关系尚不清楚.

研究的目的:

为了研究早晨时刻型对肠道微生物群组成的双向因果作用.
探索特定肠道细菌对早晨时刻型的影响.

主要方法:

采用两个样本的孟德尔随机化研究,使用欧洲联盟对早晨时代型的数据和肠道微生物群的MiBioGen联盟数据.
采用了各种统计方法,包括反变量加权 (IVW),加权模式,加权中位数,MR-Egger和简单模式.
逆门德尔随机化分析和科克兰的Q统计被用来评估因果关系和异质性.

主要成果:

早晨的时刻型对细菌家族 (Bacteroidaceae),细菌类 (Genus Parabacteroides) 和细菌类 (Genus Bacteroides) 产生保护作用.
肠道微生物群,特别是Bacteroidaceae家族,Parabacteroides属和Bacteroides属,对早晨的时间型表现出了积极的影响.
没有检测到显著的异质性或水平性.

结论:

这项研究提供了早晨时刻型和特定肠道细菌 (细菌家族,Parabacteroides属,Bacteroides属) 之间的因果关系的证据.
需要进一步的研究,包括随机对照试验,以阐明这些肠道微生物群和早晨时型相互作用背后的精确机制.

关键词:

双向的门德尔式随机化我们的肠道微生物群.早晨的时间型是早晨的时间型.单核酸多形态的单核酸多形态

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