母亲遵守地中海型饮食对微生物群组成和后代表观遗传编程的影响
Tamlyn Sasaki1, Megan Kawamura1, Chirstyn Okuno1
1John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Nutrients
|January 11, 2024
概括
母亲坚持地中海饮食对胎儿肠道微生物组和表观遗传调节产生积极影响. 这种饮食模式支持子宫内健康发育,影响新生儿肠道细菌和DNA甲基化.
科学领域:
- 围产期营养学 围产期营养学
- 微生物组研究的研究.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 母亲的饮食显著影响胎儿发育和长期健康.
- 了解饮食对胎儿肠道微生物组和表观遗传学的影响,对于预防疾病至关重要.
研究的目的:
- 评估地中海饮食模式坚持 (MDA) 对胎儿肠道微生物组和表观遗传调节的影响.
- 为了研究母亲的饮食模式与新生儿的美微生物群和DNA甲基化之间的关系.
主要方法:
- 33名孕妇每三个月填写食物频率调查问卷,并计算出替代地中海饮食 (aMED) 得分.
- 收集了带血液,胎盘组织和新生儿.
- 使用Illumina EPICarray分析的DNA甲基化;通过16srRNA测序识别的麦微生物群.
主要成果:
- 患有高MDA的母亲在新生儿中表现出更为丰富的有益细菌 (如巴氏菌和细菌菌) 的趋势.
- 鉴定出不同的甲基化区域,影响涉及胎儿发育的基因.
- 观察到MDA对胎儿在子宫内发育的有益影响.
结论:
- 怀孕期间坚持地中海饮食对胎儿肠道微生物组和表观遗传模式产生积极影响.
- 孕妇的饮食咨询对于促进健康的胎儿发育很重要.
- 这些发现指导了未来对分析和免疫-表观遗传调节的研究.
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