来自尸真菌 () 的独特生物活性物质作为有希望的多目标神经保护剂
Himadri Sharma1, Niti Sharma1, Seong Soo A An1
1Department of Bionano Technology, Gachon Bionano Research Institute, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 461-701, Gyeonggi-do, Republic of Korea.
Nutrients
|January 11, 2024
概括
科迪塞普斯含有具有抗氧化和抗炎性能的生物活性化合物. 这些化合物显示出通过保护神经元免受损伤来管理神经退行性疾病的潜力.
科学领域:
- 药理学和自然产品的研究.
- 神经科学和神经生物学
- 菌类学和传统医学的传统医学.
背景情况:
- 科尔迪塞普斯是一种寄生真菌,产生生物活性代谢物,如腺和β-葡萄糖.
- 传统上用于健康益处,Cordyceps因其治疗潜力而受到探索.
- 神经退行性疾病 (ND) 和神经创伤共享氧化应激和神经炎症等病理.
研究的目的:
- 审查Cordyceps提取物和生物活性物的神经保护机制.
- 讨论Cordyceps化合物的潜在治疗用途的安全概况.
- 为了识别神经退行性疾病的Cordyceps的新疗法实体.
主要方法:
- 对Cordyceps生物活性体的体外和体内研究的文献综述.
- 对Cordyceps化合物的分析,包括腺,和多糖.
- 对抗氧化剂,抗炎症和抗丧活性的评估.
主要成果:
- 科迪塞普斯生物活性表明抗氧化,抗炎和抗丧作用.
- 在临床前研究中,这些化合物在治疗神经退行性疾病方面表现有前途.
- 对于Cordyceps的神经保护潜力的临床试验数据有限.
结论:
- 科迪塞普斯生物活性物质具有与神经退行性疾病相关的神经保护性质.
- 需要进一步的研究和临床试验来验证治疗疗效和安全性.
- 科迪塞普斯是新型神经保护剂的潜在来源.
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