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地中海饮食,维生素D和高热量,高蛋白口服补充剂用于治疗心力衰竭患者的萨尔科佩尼亚 - 随机临床试验
Aura D Herrera-Martínez1,2, Concepción Muñoz Jiménez1,2, José López Aguilera1,3
1Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Nutrients
|January 11, 2024
概括
使用口服补充剂的营养支持改善了心力衰竭的结果,增加了身体质量和左心室喷射率 (LVEF). 这种干预,结合地中海饮食和维生素D,改善了心力衰竭患者的功能和生活质量.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 老年病的医生 老年病的医生
背景情况:
- 在心力衰竭 (HF) 患者中,营养不良和肉类是普遍存在的,结果恶化.
- 营养支持不是HF的标准护理,但口服补充剂 (OSs) 可能有益于患者.
- 建议对营养不良或肉症的HF患者进行早期营养干预.
研究的目的:
- 为了比较地中海饮食对高热量,高蛋白质OS对HF患者的影响.
- 评估营养干预措施对身体组成,功能和心脏标志物的影响.
主要方法:
- 一个开放的,受控的研究随机分配了38名HF患者在24周内食用地中海饮食或OS.
- 评估包括人体测量,肌肉声谱和生物化学标记,所有人都需要补充维生素D.
- 评估的主要结果是身体组成的变化,功能 (上行测试),生活质量,LVEF和NT-proBNP水平.
主要成果:
- 操作系统组显示身体细胞质量,瘦肉质量和体重增加,而对照组增加了脂肪质量.
- 所有患者的功能和自我报告的生活质量都显著改善.
- 左心室喷射分数 (LVEF) 增加,特别是在OS组,NT-proBNP水平在整体队列中显著下降.
结论:
- 营养支持与OS,地中海饮食和维生素D改善了HF患者的LVEF,功能和生活质量.
- 这项干预与降低NT-proBNP水平和减少住院患者有关.
- 口服补充剂提供了一个有希望的策略,以补充心力衰竭患者的医疗治疗.
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