通过主要成分分析和集群分析识别的饮食模式与结肠直肠癌风险的关联进行比较:中国的一项大型病例对照研究
Ting Ma1, Kexin Tu1, Qingjian Ou2
1Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Nutrients
|January 11, 2024
概括
富含水果,蔬菜和蛋白质来源的饮食模式与中国较低的结肠直肠癌 (CRC) 风险有关. 相反,高摄入红肉,保存食品和精制谷物会增加CRC的风险.
科学领域:
- 营养与饮食学 营养与饮食学
- 癌症流行病学 癌症流行病学
- 公共卫生 公共卫生
背景情况:
- 饮食模式提供了超越单个营养素对结肠直肠癌 (CRC) 风险的见解.
- 关于中国人口的饮食模式和CRC风险的研究有限.
- 很少有研究比较不同的统计方法来推导疾病风险预测的饮食模式.
研究的目的:
- 通过主要成分分析 (PCA) 和集群分析 (CA) 来得出饮食模式.
- 评估这些衍生饮食模式与中国人口中CRC风险的关联.
- 为了比较PCA和CA在识别疾病预测性饮食模式方面的有效性.
主要方法:
- 在中国广东省进行的一项大规模病例控制研究 (CRC病例2799例,控制2799例).
- 通过经过验证的食物频率调查问卷收集的饮食摄入数据.
- 使用PCA和CA获得的饮食模式;使用多变量逻辑回归分析的CRC风险的关联.
主要成果:
- PCA确定了四种模式;CA确定了两种 ("平衡"和"精制谷物").
- 与CRC风险的不良关联:牛奶-蛋-坚果-大豆 (aOR=0.51),蔬菜-水果 (aOR=0.61),家禽-鱼 (aOR=0.81).
- 与红肉保存食品模式相关的CRC风险增加 (aOR=2.99); 精制谷物模式 (aOR=0.59对平衡). PCA和CA产生了类似的,一致的结果.
结论:
- 红肉,保存食品和精制谷物含量高的饮食模式与CRC风险增加有关.
- 富含水果,蔬菜和优质蛋白质的饮食模式是中国预防CRC的建议.
- PCA和CA是识别与疾病相关的饮食模式的可比方法.
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