阿片类药物治疗和对氧化平衡的影响:对总氧化能力 (TOC) 和总抗氧化能力 (TAC) 的临床研究
Urszula Kosciuczuk1, Piotr Jakubow2, Katarzyna Tarnowska1
1Department of Anaesthesiology and Intensive Therapy, Faculty of Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland.
Journal of clinical medicine
|January 11, 2024
概括
治疗慢性疼痛的阿片类药物治疗会降低身体的抗氧化能力,影响氧化平衡. 氧化和布普伦诺芬表现得比特拉马多尔更好,尼古丁化加剧了这种不平衡.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 阿片类药物通常用于慢性疼痛,但它们对氧化剂-抗氧化剂平衡的影响尚不清楚.
- 关于接受长期阿片类药物治疗非癌症疼痛的患者的氧化状态的数据有限.
研究的目的:
- 通过总氧化能力 (TOC) 和总抗氧化能力 (TAC) 测量氧化状态,对接受阿片类药物治疗的慢性腰痛 (LBP) 患者进行调查.
- 为了确定与治疗持续时间或影响氧化状态的人类参数相关的潜在风险因素.
主要方法:
- 评估了血TOC和TAC在一个由28名患有慢性LBP的阿片类药物治疗患者和11名健康志愿者的对照组组成的研究小组中.
- 分析了特定阿片类药物 (布普伦诺芬,氧化,特拉马多尔) 的TOC和TAC差异,并评估了尼古丁主义的影响.
主要成果:
- 慢性阿片类药物治疗的患者与对照组相比,TAC显著降低.
- 布普伦诺芬的TOC比氧化和特拉马多尔低,而氧化的TOC最高.
- 尼古丁主义患者的TOC/TAC比率升高,表明氧化应激增加.
结论:
- 慢性阿片类药物治疗与抗氧化能力的降低有关,可以诱导氧化失衡.
- 与特拉马多尔相比,氧化和布普伦诺芬似乎具有更有利的抗氧化剂配置.
- 在接受阿片类药物治疗的患者中,尼古丁主义会加剧氧化-抗氧化失衡,无论治疗时间或剂量如何.
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