儿科慢性湿咳的呼吸道微生物组:已知情况和未来方向
Brianna Atto1, Yitayal Anteneh2, Seweryn Bialasiewicz3
1School of Health Sciences, University of Tasmania, Launceston, TAS 7248, Australia.
Journal of clinical medicine
|January 11, 2024
概括
儿童慢性湿咳,通常与长期细菌性支气管炎 (PBB) 和支气管炎有关,正通过呼吸道微生物组研究得到更好的理解. 新的多原子研究正在为改善这些严重肺部疾病的诊断和治疗铺平道路.
科学领域:
- 儿科肺病学 儿科肺病学
- 微生物组研究 微生物组研究
- 呼吸系统医学 呼吸系统医学
背景情况:
- 超过4周的慢性湿咳是儿童慢性性肺病 (CSLD) 的信号,例如长期细菌性支气管炎 (PBB) 和支气管炎.
- 早期的下呼吸道感染是关键的风险因素,可能导致持续的感染,炎症和不可逆转的肺损伤.
- 传统的基于培养的方法用于识别儿科慢性湿咳的病原体,正在被先进的'omics技术所补充.
研究的目的:
- 审查目前对呼吸道微生物组的理解,在PBB-支气管连续体内经历慢性湿咳的儿童中.
- 探索来自肠肺轴的新兴概念和与疾病内型化相关的多组学研究.
- 考虑如何不断发展的微生物群洞察力可以为慢性湿咳的新诊断和治疗策略提供信息.
主要方法:
- 文献综述侧重于儿科慢性湿咳,长期细菌性支气管炎,支气管炎和呼吸道微生物群.
- 探索多原子技术及其在呼吸道病理生物学中的应用.
- 在儿科肺部疾病的背景下,从肠肺轴整合概念.
主要成果:
- 与传统的基于培养的方法相比,omics技术的进步为呼吸系统病理生物学提供了更详细的观点.
- 新兴研究强调了肠肺轴对气道状况的潜在影响.
- 了解呼吸道微生物群对于开发儿科CSLD的基于内型的护理模型至关重要.
结论:
- 呼吸道微生物组在儿童慢性湿咳的病原发生中发挥着关键作用.
- 多原子方法和肠肺轴研究对于推动PBB和支气管切除症的内型化至关重要.
- 不断发展的微生物组知识正在推动儿童群体慢性湿咳的诊断和治疗方面的创新.
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