SCORE,弗雷明汉风险评分和估计的脉冲波速度之间的差异 基于匈牙利三代健康计划数据的血管年龄计算方法
Helga Gyöngyösi1, Gergő József Szőllősi2,3, Orsolya Csenteri2
1Department of Family Medicine, Semmelweis University, 1085 Budapest, Hungary.
Journal of clinical medicine
|January 11, 2024
概括
不同的计算血管年龄的方法产生不同的结果,影响心血管疾病风险评估. 与SCORE方法相比,弗雷明汉风险评分 (FRS) 在识别早期血管衰老方面表现出更高的灵敏度.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- 早期的血管衰老是导致心血管疾病和死亡率的重要因素.
- 目前用于计算血管年龄的方法,包括心血管风险得分,可以识别不同的个人患有早期血管衰老.
研究的目的:
- 用SCORE和Framingham风险评分 (FRS) 方法比较血管年龄计算.
- 根据估计的脉冲波速度 (ePWV) 评估早期血管衰老的个人分布.
主要方法:
- 使用SCORE和FRS计算了血管年龄,用于匈牙利大型国家查计划队列 (n=99,231).
- 估计的脉冲波速度 (ePWV) 用于定义超正常,正常和早期的血管衰老.
- 时间表年龄,基于SCORE的血管年龄,基于FRS的血管年龄和ePWV定义的血管年龄之间进行了比较,包括高血压和糖尿病的子组.
主要成果:
- 根据ePWV,弗雷明汉风险评分 (FRS) 确定了血管年龄升高的患者,具有高灵敏度 (97.3%).
- 在基于ePWV的基础上,SCORE方法在识别患有血管年龄升高的患者时显示出显著较低的灵敏度 (13.3%).
- 基于FRS的血管年龄始终高于时间年龄和基于SCORE的血管年龄,特别是在高血压和糖尿病患者中.
结论:
- 不同的血管年龄计算方法在基于人口的队列中产生不同的结果.
- 通过ePWV评估,弗雷明汉风险评分 (FRS) 在检测早期血管衰老方面似乎比SCORE方法更敏感.
- 需要进一步的研究来确定这些差异对心血管预防策略的临床影响.
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