长期1型糖尿病青少年的外视网膜和胸膜变化
Elisabetta Pilotto1, Eleonora Cosmo1, Tommaso Torresin1
1Department of Neuroscience-Ophthalmology, University of Padova, 35128 Padova, Italy.
Journal of clinical medicine
|January 11, 2024
概括
长期患有1型糖尿病的青少年显示了视网膜外层和视网膜色素上皮质厚度的增加. 这些通过光学连贯断层扫描检测到的视网膜变化与糖尿病视网膜病变状态或血糖控制无关.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 1型糖尿病 (T1D) 可以影响眼部结构.
- 长期存在的T1D可能导致糖尿病视网膜病变 (DR).
- 患有T1D的青少年早期视网膜变化需要调查.
研究的目的:
- 在患有T1D的青少年中,评估视网膜外层 (ORL),视网膜色素上皮 (RPE),胸膜 (Ch) 和胸膜 (CC).
- 为了比较糖尿病视网膜病变 (DR) 患者和没有糖尿病视网膜病变 (DR) 患者的视网膜层.
- 为了将视网膜发现与代谢参数和疾病持续时间相关联.
主要方法:
- 使用光学连贯断层扫描 (OCT) 测量ORL和RPE厚度的斑点扫描.
- 斑点OCT血管图 (OCTA) 用于量化Ch和CC的血管参数.
- 与胰岛素剂量,辅助学和代谢数据的相关性分析.
主要成果:
- 与非糖尿病视网膜病变 (noDR) 和健康对照 (HC) 相比,糖尿病视网膜病变 (DR) 眼睛的外视网膜层 (ORL) 厚度显著更高.
- 视网膜色素上皮质 (RPE) 厚度在noDR和DR眼睛相对于HC都增加.
- 两组之间没有发现胆管 (Ch) 或胆管 (CC) 血管参数的显著差异,也没有与代谢控制的相关性.
结论:
- 长期T1D的青少年表现出增加的ORL和RPE厚度.
- 这些视网膜变化独立于糖尿病视网膜病变状态,胰岛素剂量和血糖控制.
- ORL和RPE加厚可以作为青少年T1D进展的潜在成像生物标志物.
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