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Updated: Jul 5, 2025

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
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A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

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1,5-和1,8-替代的化纳弗提里丁的抗莱什曼疗效

Estela Melcón-Fernandez1, Endika Martín-Encinas2, Francisco Palacios2

  • 1Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.

Molecules (Basel, Switzerland)
|January 11, 2024
PubMed
概括

新的纳夫提里丁化合物显示出治疗莱什曼病的前景. 取代的1,8衍生品显示出显著的利什曼杀伤性活性和口服药物管理的良好潜力.

关键词:
化的1,5-纳甲基化物.化的1,8-纳甲基化物.内部巨虫 莱什曼尼亚寄生虫小鼠的肠道有机体.有关内脏的莱什曼病.

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Physical Properties of Amines01:26

Physical Properties of Amines

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Basicity of Aromatic Amines

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Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
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