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在癌症检测,诊断和预后中的生物标志物

Sreyashi Das¹, Mohan Kumar Dey¹, Ram Devireddy¹

¹Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.

Sensors (Basel, Switzerland)

|January 11, 2024

概括

生物标志物对于早期疾病检测和个性化医学至关重要. 本综述涵盖了各种癌症生物标志物,包括成像,血液,细胞,组织和遗传类型,有助于诊断和治疗.

科学领域:

生物医学科学生物医学科学
在瘤学瘤学.
诊断医学诊断医学

背景情况:

生物标志物对于疾病诊断,预后和个性化治疗策略至关重要.
生物标志物提供的客观指标有助于早期检测,干预和改善患者的治疗结果.
生物标志物是监测疾病进展,指导治疗调整和识别复发的组成部分.

研究的目的:

审查各种适用于癌症检测和诊断的生物标志物.
突出生物标志物在促进药物开发和临床试验中的作用.
提供有关瘤学当前生物标志物技术的全面概述.

主要方法:

关于癌症生物标志物的现有文献的审查.
生物标志物的分类基于诊断方式 (成像,血液,细胞,组织,遗传).
包括特定的例子,如CT,SPECT,MRI,PET,蛋白质,基因,mRNA,,CTC,IHC,RNAseq,scRNAseq和空间转录学.

主要成果:

确定了用于癌症检测和诊断的广泛生物标志物.
详细介绍了各种基于成像的诊断技术 (CT,SPECT,MRI,PET).
总结了基于血液 (蛋白质,基因,mRNA,),基于细胞 (针活检,CTC),基于组织 (IHC) 和基于基因 (RNAseq,scRNAseq,空间转录组学) 的生物标志物.

结论:

生物标志物显著提升了癌症诊断,治疗个性化和药物开发.
审查的生物标志物为早期癌症检测和监测提供了多种方法.
整合这些生物标志物可以改善患者管理和治疗策略.

关键词:

CT针活检CT针活检它们是DNA DNA DNA DNA.这就是为什么MRI是MRI.在这里,PET是PET.这是一个RNARNARNARNARNA.在RNAseqqq中使用.生物标志物生物标志物脂质脂质脂质是一种蛋白质组学蛋白质组学

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