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低成本的电子鼻子用于确定尿道感染
Alba de la Rica-Martinez1, Gemma Martínez-Muñoz2, Marta Amoros Sanjuan1
1Servicio de Microbiología, Hospital General Universitario de Elche, 03202 Elche, Spain.
Sensors (Basel, Switzerland)
|January 11, 2024
概括
电子鼻子 (eNose) 通过检测挥发性有机化合物 (VOCs) 来快速诊断尿路感染. 这项有前途的技术实现了74%的准确性,可能会彻底改变医疗诊断.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 传染病诊断 传染病诊断 传染病诊断
背景情况:
- 传统的尿液培养用于诊断感染需要48小时.
- 尿路感染 (UTI) 需要快速准确的诊断方法.
- 挥发性有机化合物 (VOC) 是感染的独特生物标志物.
研究的目的:
- 开发和验证电子鼻子 (eNose) 设备,用于快速诊断尿路感染.
- 评估eNose在尿液中识别特定感染的VOC的能力.
- 将eNose的诊断准确度与标准尿液培养进行比较.
主要方法:
- 设计了一种eNose设备,用于检测尿样中的VOC.
- 分析了203个尿样 (106个感染者,97个非感染者) 使用eNose和尿培养.
- 应用主要组件分析 (PCA) 和支持矢量机器 (SVM) 模型用于数据分析.
主要成果:
- 最初的PCA分类实现了49%的准确性.
- 使用85%的培训数据和15%的验证数据,SVM模型将分类准确度提高到74%.
- 该eNose显示,尿路感染的正确分类率为74%.
结论:
- 该eNose显示了高的诊断准确性尿路感染,超越传统方法的速度.
- eNose技术是一个有前途的,可行的,可重复的,低成本的,高精度的临床实践工具.
- 对eNose模型的进一步改进可以提高其对尿路感染的诊断性能.
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