一种来自甘草提取物 (SSE) 的新成分的抗衰老潜力
Maria João Carvalho1, Sílvia Santos Pedrosa1, Adélia Mendes1,2
1CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
International journal of molecular sciences
|January 11, 2024
概括
甘吸管提取物通过抑制关键酶和减少污染引起的炎症,显示出有希望的抗衰老益处. 然而,其透到更深层的皮肤层需要进一步的配方开发,以提高疗效.
科学领域:
- 化品科学 化品科学
- 皮肤病学 皮肤病学
- 生物化学 生物化学
背景情况:
- 对天然,可持续的化品成分的需求日益增长.
- 需要科学验证的抗衰老化合物.
- 甘吸管作为生物活性化合物的潜在来源.
研究的目的:
- 为了评估甘吸管提取物 (SSE) 的抗衰老潜力.
- 评估SSE对皮肤衰老酶的影响,关键皮肤成分的合成和反污染活性.
- 为了确定SSE的安全性和穿透皮肤的能力.
主要方法:
- 细胞毒性和敏感性测定用于角质细胞和纤维细胞.
- 酶抑制测定 (乳酶,原酶,铁酶).
- 氨酸合成促进评估.
- 使用合成膜进行体外皮肤透性测定.
主要成果:
- SSE有效抑制了弹性酶 (55%),原酶 (25%) 和铁酶 (47%).
- 在非细胞毒性度下促进了氨酸合成.
- 减少与城市污染相关的炎症标志物 (IL1-α,IL-6).
- 化合物的有限透到更深层的皮肤层.
结论:
- SSE具有显著的抗衰老特性,包括酶抑制和抗炎作用.
- 该成分在经过测试的度下安全用于化品.
- 需要配方策略来提高SSE的透率,以提高在更深层皮肤中的有效性.
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