放射治疗后的外体非编码RNA和血液图用于预测宫癌患者的早期死亡
1Gynecologic Cancer Center, Department of Radiation Oncology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
International journal of molecular sciences
|January 11, 2024
概括
微RNA (miR)-574-3p和长跨基因非蛋白质编码 (LINC) 01003的血水平可以预测同时接受化疗放射治疗 (CCRT) 的宫癌患者的早期死亡. 这些非编码RNAs (ncRNAs) 与血细胞动态相结合,提供预后生物标志物,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物 生物标志物
背景情况:
- 同时的化疗-放射治疗 (CCRT) 可以矛盾地加速疾病进展和早期死亡 (ED) 在各种癌症.
- 在接受CCRT的宫癌患者中,ED的预测生物标志物对于个性化治疗策略至关重要.
研究的目的:
- 评估血外体非编码RNA (ncRNA) 水平和血细胞动态与在接受CCRT的宫癌患者的早期死亡 (ED) 预测之间的关联.
- 在这个患者队列中确定ED的新型预后生物标志物.
主要方法:
- 倾向性得分匹配用于比较370名接受CCRT治疗的患者的完整血液样本 (CBC).
- 在42名患者中,在CCRT前后分析了外体ncRNA和信使RNA (mRNA) 表达差异 (对数折叠变化,log2FC).
- 网络构建和多重回归确定了与CBC动态和ED相关的关键RNA.
主要成果:
- 在队列1 (120名患者) 中,绝对中性粒细胞计数 (ANC) 的增加与ED相关.
- 微RNA (miR) -574-3p和长跨基因非蛋白质编码 (LINC) 01003表达与ANC和血红蛋白相关,分别在队列2.
- 结合miR-574-3p-LINC01003-ACOT9 log2FC < 0的患者显示,30个月的疾病特异性存活率有所改善.
结论:
- 血中的miR-574-3p和LINC01003水平,与CBC动态相结合,是宫癌患者早期死亡的潜在预后生物标志物.
- 这些ncRNA可能有助于在CCRT期间对患者进行分层风险评估和治疗规划.
更多相关视频
10:35A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
Published on: April 5, 2018
10.4K
08:12Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
5.5K
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:36Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K