相关实验视频

Updated: Jul 5, 2025

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

透甲酸 (PFOA) 暴露会影响卵巢和卵细胞发育,从而影响生育能力

Han Zhang¹, Lulu Han¹, Lijun Qiu¹

¹School of Fisheries, Zhejiang Ocean University, Zhoushan 316022, China.

International journal of molecular sciences

|January 11, 2024

概括

暴露在酸中会损害斑马鱼的卵巢,损害生育能力和卵细胞的发育. 这种持续的污染物会引发炎症反应,突出显示生殖毒性风险.

科学领域:

环境毒理学环境毒理学
生殖生物学生殖生物学
斑马鱼模型斑马鱼模型

背景情况:

perfluorooctanoic 酸 (PFOA) 是一种广泛存在的持久性有机污染物.
在卵巢中积聚PFOA,在小鼠中引起生殖毒性.
对PFOA对生育能力的影响的确切机制尚未完全理解.

研究的目的:

研究PFOA对斑马鱼生育能力的影响.
阐明PFOA引起的生殖功能障碍的潜在机制.

主要方法:

斑马鱼被暴露在PFOA (100毫克/升15天).
评估了受精,化和卵细胞成熟率.
使用组织学和转录组测序分析了卵巢组织.
在实验室中对卵子细胞的发育进行了监测.

主要成果:

暴露于PFOA显著降低了受精和化成功.
观察到卵巢损伤和成熟卵细胞百分比下降.
在体外抑制卵子细胞发育的PFOA.
转录组分析揭示了284个差异表达基因 (DEGs),主要在补充和凝固途径中.
确定了与免疫反应相关的基因,如LOC108191474和ZGC:173837.
暴露于PFOA诱导了卵巢中的炎症反应.

结论:

暴露于PFOA会导致卵巢损伤,并损害斑马鱼的生育能力.
该机制涉及PFOA诱导的炎症和卵细胞发育的干扰.
PFOA对生殖健康构成重大风险.

关键词:

它们的受精能力是受精能力.卵子细胞卵子细胞 perfluorooctanoic 酸的使用情况.斑马鱼是一种斑马鱼.

更多相关视频

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

相关概念视频

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Infertility in Females

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...