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相关概念视频

Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

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Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

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Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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相关实验视频

Updated: Jul 5, 2025

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

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经典亚型如何对应于无形皮肤炎中的内型?

Tsuyoshi Suzuki1, Shumpei Kondo1, Yasuaki Ogura1

  • 1Department of Dermatology & Skin Oncology, Chutoen General Medical Center, 1-1 Shobugaike, Kakegawa 436-8555, Japan.

International journal of molecular sciences
|January 11, 2024
PubMed
概括

亚topic皮肤炎 (AD) 亚型正在从表型演变为内型,以实现个性化治疗. 了解内型,特别是基于细胞因子的内型,对于为患有AD的个体患者量身定制疗法至关重要.

关键词:
亚托邦性皮肤炎的发生终极类型 终极类型 终极类型外在类型的外在类型.内在类型是一种内在类型.现象型 现象型 是一种现象型.亚型子类型 亚型子类型

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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科学领域:

  • 皮肤病学 皮肤病学
  • 免疫学 免疫学 免疫学
  • 遗传学 遗传学 是一个

背景情况:

  • 亚托邦性皮肤炎 (AD) 是一种复杂的皮肤疾病,患者表现不同.
  • 传统的AD分类依赖于表型特征,这些特征可能无法完全捕捉潜在的疾病机制.
  • 阿尔茨海默病的异质性需要更精确的患者分层方法.

研究的目的:

  • 审查阿托皮性皮肤炎内型化概念.
  • 探索各种分层方法,包括细胞因子概况,屏障功能和生物标志物.
  • 讨论经典AD亚型与新兴内型之间的相关性.

主要方法:

  • 关于AD机制和内型定型的最新发现的文献综述.
  • 分析不同的内型类别分类系统 (基于细胞因子,基于生物标志物).
  • 经典AD亚型 (外部/内在,种族,基于年龄) 与拟议的内型的比较.

主要成果:

  • 内型鉴定提供了比表型鉴定更准确的患者特征.
  • 基于细胞因子的内型 (类型2,类型1,类型3高) 特别有用.
  • 基于生物标志物的内型鉴定正在出现,用于个性化治疗策略.

结论:

  • 在制定个性化治疗选择方面,阿尔茨海默病内型化是至关重要的.
  • 将经典亚型与内型对齐将有助于临床理解和应用.
  • 需要进一步的研究来将内型化整合到AD管理的日常临床实践中.