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Updated: Jul 5, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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考虑SHP-1作为瘤治疗的分子标

Seyeon Lim1, Ki Won Lee2, Jeong Yoon Kim3

  • 1Division of Applied Life Science (BK21 Plus), Gyeongsang National University, Jinju 52828, Republic of Korea.

International journal of molecular sciences
|January 11, 2024
PubMed
概括

像SHP-1这样的蛋白氨酸酸酶 (PTP) 在癌症中起着复杂的作用. 开发针对SHP-1的向疗法需要考虑其在瘤细胞和微环境中的双重作用.

关键词:
Src同质区2 (SH2) 域含有酸酶1的区域.抗癌药物是一种抗癌药物.蛋白质氨酸酸酶是一种蛋白质氨酸酸酶.接收器氨酸激酶的受体

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