评估血清和水平作为结核病和COVID-19严重程度的预测生物标志物:罗马尼亚前性研究
Ramona Cioboata1,2, Corina Maria Vasile3, Mara Amalia Bălteanu4,5
1Pneumology Department, University of Medicine and Pharmacy, 200349 Craiova, Romania.
International journal of molecular sciences
|January 11, 2024
概括
低血清和水平与严重的结核病 (TB) 和COVID-19有关. 这些电解质失衡可能成为预测患者疾病严重程度的重要生物标志物.
科学领域:
- 医学研究 医学研究
- 临床诊断 临床诊断 临床诊断
- 传染性疾病 传染性疾病
背景情况:
- 罗马尼亚在2020年报告了欧盟中结核病 (TB) 发病率最高的国家.
- 随着COVID-19的流行,包括结核病管理在内的医疗保健受到破坏.
- 结核病和COVID-19都与显著的发病率,死亡率和潜在的电解质失衡有关.
研究的目的:
- 研究结核病和COVID-19患者的疾病严重程度与血清和水平之间的相关性.
- 评估这些电解质作为疾病进展和严重程度的生物标志物的潜力.
主要方法:
- 对146名患者 (74名结核病患者,72名COVID-19患者) 进行了前性研究.
- 分析了血清和水平,以及肺功能.
- 统计分析包括克鲁斯卡尔-瓦利斯测试,恩程序和ROC分析.
主要成果:
- 较低的血清和水平与严重形式的结核病和COVID-19有显著的相关性.
- 严重的结核病病例 (多个腔) 显示血清和含量显著降低.
- ROC分析表明血清和是COVID-19严重程度的潜在预测因素.
结论:
- 低血清和水平与结核病和COVID-19的严重程度增加有关.
- 这些电解质显示出作为预测疾病严重程度和帮助临床决策的潜在生物标志物的前景.
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