在乳腺癌和泌尿癌的治疗反应中使用抗过敏药
Ana Catarina Matos1,2,3, João Lorigo4, Inês Alexandra Marques1,2,3
1Coimbra Institute for Clinical and Biomedical Research (iCBR), Area of Environment, Genetics and Oncobiology (CIMAGO), Biophysics Institute, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
像利多卡因这样的局部麻醉剂在体外显示出有前途的抗瘤作用,特别是与多塞塔克塞尔一起,有利于前列腺癌患者. 然而,慢性阿片类药物使用与这些患者的生存率较差有关.
科学领域:
- 在瘤学瘤学.
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗癌剂,特别是局部麻醉剂对瘤进展和患者存活时间的影响还不清楚.
- 现有研究提出了关于局部麻醉剂在癌症治疗中的疗效的相互矛盾的数据.
研究的目的:
- 为了研究在乳腺,前列腺和膀癌细胞系上的利多卡因,罗皮瓦卡因和勒沃布皮瓦卡因的体外抗瘤作用.
- 评估这些局部麻醉剂与标准化疗的联合作用.
- 探索慢性阿片类药物使用与转移性前列腺癌患者的临床结果之间的关联.
主要方法:
- 在体外测试评估MCF7,PC3,LNCaP,TCCSUP和HT1376细胞系的细胞增殖,活力,死亡和迁移.
- 一项对200名转移性前列腺癌患者的横截面研究,分析了阿片类药物治疗,剂量,持续时间,疾病进展和整体存活率.
主要成果:
- 局部麻醉剂在体外表现出选择性抗瘤活性,与多塞塔克塞尔结合时有效性提高.
- 在转移性前列腺癌患者中,慢性阿片类药物给药与显著减少的整体存活率和无进展的存活率相关.
结论:
- 局部麻醉剂可能在治疗前列腺癌方面提供额外的治疗价值,特别是当与多塞塔克塞尔一起使用时.
- 在前列腺癌患者慢性使用时,阿片类止痛药可能会对生存结果产生负面影响.
- 需要进一步的大规模前性研究来确认阿片类药物在癌症患者中使用的临床影响.
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