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激素受体阳性乳腺癌中的雄激素受体

Ashfia Fatima Khan¹, Samaneh Karami¹, Anthony S Peidl¹

¹Center for Nuclear Receptors & Cell Signaling, Department of Biology & Biochemistry, University of Houston, 3517 Cullen Blvd, SERC Bldg., Rm 3010, Houston, TX 77204-5056, USA.

International journal of molecular sciences

|January 11, 2024

概括

激素受体阳性乳腺癌 (HR+BCa) 的雄激素受体 (AR) 功能复杂,影响内分泌疗法耐药性. 研究AR结构和向疗法为治疗先进的HR+BCa.提供了新的希望.

科学领域:

在瘤学瘤学.
内分泌学在内分泌学.
分子生物学分子生物学

背景情况:

激素受体阳性乳腺癌 (HR+BCa) 通常对内分泌疗法 (ET) 有反应,但耐药性 (ET-R) 会导致转移性疾病.
对于ET-R HR+ BCa存在有限的向疗法,造成未满足的临床需求.
雄激素受体 (AR) 是HR阴性乳腺癌的点,但其在HR+BCa中的作用是复杂的和争论的.

研究的目的:

审查AR在HR+BCa中的双重作用,探索其对预后和ET耐药性的影响.
讨论AR结构和翻译后修改如何影响其在乳腺癌中的功能.
介绍针对乳腺癌的AR向剂的已完成和正在进行的临床试验.

主要方法:

在各种乳腺癌亚型中对AR功能的文献综述.
对已完成和正在进行的涉及AR向剂的临床试验的分析.
讨论结构和翻译后修改对AR活动的影响.

主要成果:

在HR+BCa中,AR与良好的预后相关,但也促进ET耐药性.
抗逆转基因抗剂的疗效有限,而选择性抗逆转基因调节剂在临床试验中显示出有前途.
了解AR结构和修改是阐明其不一致的行动的关键.

结论:

在HR+BCa中AR的复杂作用需要进一步研究其结构和修改.
针对AR途径,特别是选择性调制剂,是ET-R HR+ BCa的有前途的治疗策略.
未来的研究应该专注于新型小分子和嵌合体药物,以加强HR+BCa治疗.

关键词:

针对AR的药物 5 针对AR的药物 SUMO 基化 4 基化雄激素受体 1 雄激素受体 1 临床试验 6 临床试验 6 激素阳性乳腺癌 2 2 翻译后的修改 3 翻译后的修改

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