益生菌 Bacillus licheniformis ZW3 缓解DSS诱导的大肠炎,并增强肠道平衡
Dan Jia1,2, Yingying Li1, Yingjie Wang1
1State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
International journal of molecular sciences
|January 11, 2024
概括
巴西菌ZW3是一种来自驼便的益生菌,对治疗大肠炎有前途. 在患有炎症性肠病的小鼠中,它减少了炎症并改善了肠道健康.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 细菌种在食品和益生菌中广泛使用,但它们对肠道疾病的影响尚不清楚.
- 炎症性肠病 (IBD),如大肠炎,涉及复杂的免疫反应和肠道失调.
研究的目的:
- 为了研究Bacillus licheniformis ZW3 (ZW3) 在硫酸 (DSS) 诱导的大肠炎的小鼠模型中的治疗潜力.
主要方法:
- 向患有DSS诱导的大肠炎的小鼠给予ZW3.
- 评估临床症状,结肠组织学,炎症标志物 (IL-1β,TNF-α,IL-6),结肠屏障蛋白 (MUC2,ZO-1,ocludin),肠道微生物群组成和尿酸水平.
主要成果:
- 在大肠炎小鼠中,ZW3部分缓解了体重减轻,疾病活动指数 (DAI) 和结肠缩短.
- 通过增加MUC2,ZO-1和奥克卢丁,ZW3抑制了炎症标志物并增强了结肠屏障完整性.
- ZW3调节了肠道微生物群,丰富了有益的Lachnospiraceae_NK4A136_组,减少了有害的Escherichia-Shigella,同时使高尿酸水平正常化.
结论:
- 细菌菌ZW3在小鼠中显示出对DSS诱导的大肠炎的保护作用.
- ZW3改善炎症,恢复结肠屏障功能,并重新平衡肠道微生物群.
- 这些发现表明ZW3在管理与炎症相关的肠道疾病方面的潜在应用.
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