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与HCC相关的lncRNAs:作用和机制

Mimansha Shah¹, Devanand Sarkar²

¹Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.

International journal of molecular sciences

|January 11, 2024

概括

长非编码RNAs (lncRNAs) 在肝细胞癌 (HCC) 的发展中至关重要,影响基因调节和疾病进展. 了解lncRNA的作用为HCC提供了新的诊断和治疗策略,包括与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 相关的诊断和治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

肝细胞癌 (HCC) 是一个主要的全球健康问题,由病毒性肝炎和与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 加剧.
遗传和表观遗传变化,包括失调的信号通路,是HCC发展的关键驱动因素.
表观遗传机制,如DNA甲基化,基因素修饰和非编码RNA,在HCC病变发生过程中起着至关重要的作用.

研究的目的:

审查长非编码RNAs (lncRNAs) 在HCC的发展和进展中的关键作用.
探索lncRNAs在与MAFLD和病毒性肝炎相关的HCC中的参与.
突出 lncRNAs 作为诊断生物标志物,预后指标和 HCC 精准医学中的治疗点的潜力.

主要方法:

文献综述侧重于lncRNAs在HCC中的功能.
对调查肝癌发生过程中 lncRNA 失调的研究进行分析.
对HCC中 lncRNA介导的基因调控进行当前研究的综合.

主要成果:

长非编码RNAs (lncRNAs) 在HCC中显著失调.
lncRNAs通过染色体调节,转录调节,miRNA海绵化和结构功能影响HCC进展.
lncRNA失调与由MAFLD和病毒性肝炎驱动的HCC发展有关.

结论:

lncRNAs是HCC发病过程中的关键调节者,影响关键的分子通路.
lncRNAs作为HCC早期诊断和预后的生物标志物具有显著的前景.
准 lncRNAs 是一种有希望的途径,用于新型的精确医学策略在HCC治疗中.

关键词:

肝细胞癌是肝细胞癌.长非编码RNA是什么意思预后预后预后治疗治疗治疗治疗治疗治疗

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