儿科炎性肠病中的甲原体古生物与疾病类型和活动相关
Agata Anna Cisek1, Edyta Szymańska2, Aldona Wierzbicka-Rucińska3
1Department of Pathomorphology, The Children's Memorial Health Institute, Av. Dzieci Polskich 20, 04-730 Warsaw, Poland.
International journal of molecular sciences
|January 11, 2024
概括
重要肠道微生物 - - 甲原性古生物 - - 在患有儿科炎症性肠病 (IBD) 的儿童中显著减少,包括克罗恩氏病.
科学领域:
- 微生物学 微生物学
- 儿科胃肠病学 儿科胃肠病学
- 肠道微生物组研究研究
背景情况:
- 肠道微生物群失调与炎症性肠道疾病 (IBD) 有关.
- 关于甲基生物的研究有限,特别是在儿科IBD人群中.
- 甲基生物是古老生物,它们在肠道生态系统功能中发挥作用.
研究的目的:
- 在儿科IBD中量化总甲原体和特定子组 (Methanobrevibacter smithii,Methanosphaera stadtmanae,Methanomassiliicoccales).
- 为了将甲素丰富度与克罗恩病 (CD) 和性结肠炎 (UC) 的类型和活性相关联.
- 为了比较IBD患者的甲素水平与健康对照.
主要方法:
- 使用定量实时PCR测定便样本中的甲原丰度.
- 使用儿科克朗氏病活动指数 (PCDAI),儿科性结肠炎活动指数 (PUCAI) 和便calprotectin (FCP) 评估疾病活性.
- 积极/不活跃的CD和UC组之间的数据和对照组的数据进行了比较.
主要成果:
- 与对照人群相比,患有CD和UC的儿童的甲素总计数显着较低.
- 与对照组相比,UC患者的甲素患病率降低了.
- 不活跃的UC患者显示了较低的Methanobrevibacter smithii水平,以及Methanosphaera stadtmanae和FCP度之间的正相关性.
结论:
- 在儿科IBD中,肠道甲素的丰度发生显著变化.
- 甲素水平与儿童克罗恩病和性结肠炎的类型和疾病活性相关.
- 这些发现凸显了甲基生物在儿科IBD病理生理学中的潜在作用.
关键词:
克罗恩氏病是什么 克罗恩氏病是什么考古学是指古物质 (archaea) 是指古物质.孩子们的孩子们的孩子们的孩子们.便中的calprotectin是一种便的calprotectin.炎症性肠病是一种炎症性肠病.甲氧化物是一种甲基化物.性结肠炎是一种更多相关视频
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