精液参数与重复流产之间的关联:对元分析的总体审查
Lei Zhang1, Honglin Li1, Letian Han1,2,3
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
The journal of obstetrics and gynaecology research
|January 11, 2024
概括
男性因素显著影响重复性妊娠损失 (RPL). 高质量的证据将精子DNA碎片化与RPL联系起来,而传统的精液参数显示出较弱的关联. 需要进一步的研究.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 遗传学 是一个遗传学.
背景情况:
- 经常性流产 (RPL) 影响了许多夫妇,越来越多的证据表明男性因素.
- 之前对男性精液质量和RPL的元分析已经产生了不一致的结果.
研究的目的:
- 系统地审查和评估将男性精液参数与RPL联系起来的证据.
- 评估有关此主题现有元分析的质量和有效性.
主要方法:
- 在主要数据库 (PubMed,Cochrane图书馆,EMBASE,科学网,Scopus) 进行了全面的文献搜索.
- 包括七个元分析,检查了与RPL相关的九个精液参数.
- 评估了方法质量,并使用随机效应模型重新合成数据.
主要成果:
- 包含的研究的方法质量通常低至非常低.
- 强烈暗示性证据 (II类) 支持精子DNA碎片化 (SDF) 和RPL之间的关联.
- 在精子度,正常形态,变形率和总运动性方面发现了有意义的证据 (III类).
- 较弱的证据 (第四类) 将精子数量和精子数量与RPL联系起来;对于精子pH没有发现任何关联.
结论:
- 男性精子DNA碎片化 (SDF) 显示出与II级证据的复发性妊娠丧失 (RPL) 有着强烈的关联.
- 传统的精液参数具有较低的证据水平 (III和IV类),将其与RPL联系起来.
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