膀纳米载体:一种潜在的平台,用于局部/透皮输送抗生素
Mohit Chadha1, Deepinder Singh Malik2
1Baba Farid College of Pharmacy, Mullanpur, District Ludhiana, 142023, India.
Recent patents on nanotechnology
|January 11, 2024
概括
膀纳米载体为局部抗生素输送提供了一个有前途的解决方案,克服耐药性并改善患者的服药性. 与传统治疗相比,这些先进的系统提高了药物的疗效,减少了副作用.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 抗生素耐药性对治疗细菌感染构成了重大挑战.
- 传统的局部抗生素配方存在诸如频繁剂量,毒性和患者不良坚持等缺点.
- 膀纳米载体为改善局部/透皮抗生素输送提供了替代方案.
研究的目的:
- 审查各种囊泡纳米载体用于局部/透皮抗生素的应用.
- 总结这些纳米载体系统的相关专利.
主要方法:
- 使用PubMed,谷歌学者和谷歌专利进行了全面的文献搜索.
- 审查的重点是研究囊泡纳米载体用于抗生素输送的研究.
主要成果:
- 膀纳米载体系统在实验室和临床前显著的有效性,用于局部/通过皮肤输送的抗生素.
- 各种纳米载体类型,包括脂质体,体和纳米乳液,显示出潜在的.
结论:
- 膀纳米载体有可能减轻常规抗生素输送的副作用,例如频繁的剂量和不良遵守.
- 临床验证和可扩展的制造对于这些系统的市场引入至关重要.
相关概念视频
01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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01:22Drug Delivery: Miscellaneous Routes
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
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01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
456
01:22Routes of Drug Administration: Overview
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Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
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01:15Non-Oral Extravascular Drug Absorption Routes
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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
216