通过TPGS介导的转基因增强黄素的通过皮肤给药通过 对变形性和稳定性的影响
Teng Guo1, Chenming Zhang1, Yuling Chen1
1Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Current drug delivery
|January 11, 2024
概括
增强的D-α-托科法醇酸聚乙烯甘醇糖酸盐 (TPGS) 转基因组显著改善了黄素.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 表面活性剂增强了透体的通过皮肤的透性.
- 用作边缘激活剂的D-α-托科法醇酸聚乙烯甘醇酸盐 (TPGS).
- 通过皮肤输送黄素 (Cur) 的跨皮层细胞.
研究的目的:
- 准备和优化TPGS介导的黄素载荷转基因组 (Cur@TES).
- 评估Cur@TES,以提高通过皮肤传递和抗炎作用.
- 研究TPGS在改善跨细胞体功能中的作用.
主要方法:
- 优化了Cur@TES的配方,其特点是形态,颗粒大小,捕获效率 (EE) 和药物负载 (DL).
- 稳定性,可变形性和体外透皮透性试验进行.
- 光成像和小鼠耳朵胀模型用于评估皮肤分布和抗炎活性.
主要成果:
- 优化的Cur@TES显示圆形/圆形,粒子大小为131.2 ± 7.2 nm,EE为97.68 ± 2.26%,DL为6.58 ± 0.62%.
- 与Cur@ES.相比,Cur@TES表现出增强的稳定性和可变形性.
- 观察到皮肤药物保留的显著增加和皮肤分布的增强.
- 在小鼠模型中,Cur@TES显示出显著的抗炎作用.
结论:
- 通过TPGS介导的转基因组为黄素通过皮肤输送提供了显著的优势.
- 增强的稳定性,可变形性和皮肤透性有助于改善治疗结果.
- 这种方法提供了一种新的策略,可以有效地通过皮肤递送药物.
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