德克萨米他排泄的多多巴胺聚烯酸聚烯酸-多 (乳糖-co-糖醇) 酸用于治疗气管狭窄症
Jacob Morand1, Phillip McClellan2, Ilaha Isali2
1Advanced Platform Center, Louis Stokes Cleveland Veteran Affairs Medical Center, Cleveland, Ohio, USA.
Journal of biomedical materials research. Part A
|January 11, 2024
概括
这项研究开发了一种用于气管狭窄的新型支架,将多多巴胺涂层用于上皮化和德克萨米微粒结合起来,以减少炎症. 该支架显示出有前途的机械性能和药物输送,用于治疗气管缩.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术纳米技术
背景情况:
- 气管狭窄,通常是由伤害引起的,涉及炎症和纤维化,导致治疗后复发.
- 类固醇在通过抑制炎症和促进愈合来控制气管狭窄症方面至关重要.
- 有效的气管狭窄症管理需要减少炎症和增强表皮质化的策略,以防止复缩.
研究的目的:
- 评估多多巴胺聚烯酸 (PCL) 支架的体外有效性,该支架涂有德克萨米他排泄的多多乳糖糖酸微粒 (μPLGA),用于气管狭窄.
- 评估支架促进上皮质化和减少炎症的能力.
- 确定用于气管狭窄症治疗的新型支架的机械性能和药物释放特征.
主要方法:
- 使用拉曼光谱学对PCL支架的多多巴胺化和表征.
- 在甲基释放后对表皮细胞扩散和巨细胞活性 (iNOS表达) 的体外评估.
- 在30天内使用高性能液态染色学量化德克萨米他释放量.
- 机械测试,包括从尸体气管中拉出测试和压缩环形刚度测量.
主要成果:
- 聚多巴胺治疗显著增强了PCL支架上上皮质细胞的扩散 (p < .05).
- 从μPLGA微粒中释放的甲显著减少了巨细胞的激活,由细胞面积和iNOS生产的减少表明 (p < .05).
- PCL-μPLGA支架表现出足够的机械强度用于气管固,并提供生物机械支,防止气道崩,硬度约为子气管的1/10 .
结论:
- 一个装有甲松的PCL-μPLGA支架平台有效地输送甲松,并具有足够的机械特性用于气管植入.
- PCL的多多巴胺增强了上皮层的形成,这对于预防气管缩至关重要.
- 开发的多多巴胺PCL-μPLGA支架是进一步体内评估气管狭窄症治疗的有希望的候选人.
相关概念视频
01:21Tracheostomy Decannulation
176
Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
176
01:16Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
601
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
601
01:23Oxygen Delivering System III: Tracheostomy and T-piece
977
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
977