婴儿的一个常见问题:维生素B12缺乏
1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Başkent University School of Medicine, Ankara, Türkiye.
The Turkish journal of pediatrics
|January 11, 2024
概括
营养维生素B12 (VB12) 缺乏症在婴儿中很常见,其中98%的病例发生在0-2岁儿童中. 早期诊断和治疗对于预防幼儿不可逆转的神经损伤至关重要.
科学领域:
- 儿科血液学 儿科血液学
- 营养缺乏症 营养缺乏症
- 临床研究 临床研究
背景情况:
- 营养维生素B12 (VB12) 缺乏会导致贫血,发育不良和发育迟缓.
- 患有VB12缺乏症的母亲所生婴儿的风险增加.
- 迅速干预至关重要,以避免永久的神经损伤.
研究的目的:
- 调查诊断为VB12缺乏症的儿科患者的临床和实验室特征.
- 确定VB12缺乏症在幼儿中的流行率和人口统计模式.
主要方法:
- 对接受小儿血液学门诊的患者进行了回顾性分析.
- 纳入标准:2015年1月至2020年2月期间被诊断患有VB12缺乏症的患者.
- 通过医院自动化系统收集的数据,包括临床和实验室参数.
主要成果:
- 在3198名患者中有129人 (4%) 发现了VB12缺乏症,主要在0-2岁的婴儿中 (98%).
- 在55%的病例中观察到母亲的VB12缺乏,其中24%的母亲的水平低于200 pg/ml.
- 负载治疗显著增加了VB12水平,平均水平从负载后的171.63 pg/ml上升到769 pg/ml.
结论:
- 婴儿和幼儿 (0-2岁) 普遍存在VB12缺乏症,需要早期诊断和治疗.
- 由于神经复杂症的高发病率和风险,建议在这个年龄段进行VB12缺乏的例行查.
- 进一步研究婴儿VB12缺乏症的预防策略是有必要的.
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